In healthy individuals, the arteries transport blood rich in oxygen and nutrients from the heart to the rest of the body, including the limbs such as the legs and arms. Narrowing of these arteries over time, due to the buildup of fatty deposits called plaque, leads to ischaemia in the limbs. The condition of clogged arteries in the limb is known as peripheral arterial disease.
Intervention available for this condition is surgical revascularization via vascular bypass. However, in certain condition where vascular bypass treatment is fairly impossible, it may lead to amputation and in severe cases, death. Hence, the encouraging results of clinical trials with Stempeucel® filled the gap of treatment needed to salvage damaged limb caused by CLI due to peripheral arterial disease.